Alcohol consumption and maxillofacial fractures in times of Covid-19: a cross-sectional study in a cuban university hospital / Consumo de alcohol y fracturas maxilofaciales en tiempos de Covid-19: un estudio transversal en un hospital universitario cubano

Introduction: The consumption of alcoholic beverages reduces the body's ability to deal with dangerous situations and exposes people to trauma. Objective: To determine the association between the consumption of alcoholic beverages and the characteristics of maxillofacial fractures treated at a Cuban university hospital in the context of COVID-19. Material and Methods: An observational, analytical, and cross-sectional study was carried out in the Maxillofacial Surgery unit at the "Carlos Manuel de Céspedes" General University Hospital during the year 2020. Prevalence ratios, 95% confidence intervals and p-values were obtained using generalized linear models. Results: In 58.23% of the cases, fractures were related to the consumption of alcoholic beverages. The fundamental etiology was interpersonal violence (47.75%), regardless of the consumption of alcoholic beverages. There was a prevalence of patients with nasal fractures (n=98; 55.06%), among which, 35.71% had consumed alcoholic beverages at the time of the trauma. Being male (p=0.005), the lack of university studies (p=0.007), the need for surgical treatment (p<0.001), the fractures of the zygomaticomaxillary complex (p=0.023), and the traumas that occurred during the weekends (p<0.001) or during the month of June (p=0.029) were factors associated with a higher frequency of fractures related to the consumption of alcoholic beverages. There was a lower frequency of fractures associated with alcohol consumption during the months of January (p=0.006) and March (p=0.001). Conclusion: Six out of ten cases were under the influence of alcoholic beverages. There was a greater number of young and male patients, mainly due to interpersonal violence.

Introducción: La ingestión de bebidas alcohólicas disminuye la capacidad del organismo para enfrentar situaciones de peligro y lo predispone a sufrir traumatismos diversos. Objetivo: Determinar la asociación entre el consumo de bebidas alcohólicas y las características de las fracturas maxilofaciales atendidas en un hospital universitario cubano en el contexto de la COVID-19. Material y Métodos: Estudio observacional, analítico y transversal realizado en el servicio de Cirugía Maxilofacial del Hospital General Universitario "Carlos Manuel de Céspedes" durante el 2020. Se obtuvieron razones de prevalencia, intervalos de confianza a 95% y valores p mediante modelos lineales generalizados. Resultados: En el 58.23% de los casos las fracturas se relacionaron con la ingestión de bebidas alcohólicas. La etiología fundamental fue la violencia interpersonal (47.75%), independientemente del consumo o no de bebidas alcohólicas. Predominaron los pacientes con fracturas nasales (n=98; 55.06%), en los que el 35.71% había consumido bebidas alcohólicas en el momento del trauma. El sexo masculino (p=0.005), la carencia de estudios universitarios (p=0.007), la necesidad de tratamiento quirúrgico (p<0.001), las fracturas del complejo cigomático-maxilar (p=0.023), los traumas sucedidos durante los fines de semanas (p<0.001) o durante el mes de junio (p=0.029) fueron factores asociados a una mayor frecuencia de fracturas relacionadas con el consumo de bebidas alcohólicas. Hubo menor frecuencia de fracturas asociadas a este consumo durante los meses de enero (p=0.006) y marzo (p= 0.001). Conclusión: Seis de cada diez casos estuvieron bajo los efectos de la ingestión de bebidas alcohólicas. Existió una mayor afectación de pacientes jóvenes, masculinos, a causa principalmente de la violencia interpersonal.

[Translated article] SARS-CoV-2 Infection in Patients With or at Risk for Venereal Infections: Incidence and Associated Factors in a Sexual Health Clinic.

BACKGROUND AND OBJECTIVE: SARS-CoV-2 is more easily spread by close contact, which is inherent to sexual intercourse. People with, or at risk for, sexually transmitted infections (STIs) may therefore have higher rates of COVID-19. The aim of this study was to estimate SARS-CoV-2 antibody seroprevalence in people seen at a dedicated STI clinic, compare our findings to the estimated seroprevalence in the local general population, and study factors associated with SARS-CoV-2 infection in this setting. MATERIAL AND METHODS: Cross-sectional observational study including consecutive patients older than 18 years of age who had not yet been vaccinated against COVID-19 and who underwent examination or screening at a dedicated municipal STI clinic in March and April 2021. We ordered rapid SARS-CoV-2 serology and collected information on demographic, social, and sexual variables, STI diagnoses, and history of symptoms compatible with SARS-CoV-2 infection. RESULTS: We studied 512 patients (37% women). Fourteen (24.2%) had a positive SARS-CoV-2 test. Variables associated with positivity were use of FFP2 masks (odds ratio 0.50) and a higher-than-average number of sexual partners (odds ratio 1.80). Use of FFP2 masks was not randomly distributed in this sample. CONCLUSIONS: Sexually active members of the population in this study had a higher incidence of SARS-CoV-2 infection than the general population. The main route of infection in this group appears to be respiratory, linked to close contact during sexual encounters; sexual transmission of the virus is probably limited.

Respiratory syncytial virus outbreak during the COVID-19 pandemic. How has it changed?

INTRODUCTION: The epidemiology of respiratory syncytial virus (RSV) infection has changed during the COVID-19 pandemic. Our objectives were to describe the RSV epidemic in 2021 and compare it with the previous years to the pandemic. METHODS: Retrospective study performed in Madrid (Spain) in a large pediatric hospital comparing the epidemiology and clinical data of RSV admissions during 2021 and the two previous seasons. RESULTS: 899 children were admitted for RSV infection during the study period. During 2021, the outbreak peaked in June and the last cases were identified in July. Previous seasons were detected in autumn-winter. The number of admissions in 2021 was significantly lower than in previous seasons. There were no differences between seasons regarding age, sex or disease severity. CONCLUSION: RSV hospitalizations during 2021 in Spain moved to summer with no cases in autumn and winter 2020-2021. Unlike other countries, clinical data were similar between epidemics.

Clinical-Epidemiological Profile of Hospitalized Patients with the New Coronavirus That Evolved to Death in Hospital of Infectious Diseases

Objective: to describe the clinical-epidemiological profile of patients hospitalized with the new coronavirus, who died at a referral hospital for infectious diseases. Method: cross-sectional study, conducted in a public hospital in the State of Ceara, Brazil, from January to March 2021, through access to the 244 medical records of patients who were hospitalized with COVID-19, with confirmatory examination of RT-PCR, rapid test, serology or tomography, between March and December 2020, and who evolved to death during hospitalization. Results: public formed by men, aged 60 years or older, married/stable union, retired, residing in the capital, with associated hypertension and diabetes, who died in March and June, in the ward. The main signs and symptoms at admission, they were oxygen saturation in ambient air below 92%, dyspnea, severe acute respiratory syndrome and fever;the main clinical indication for admission was respiratory failure;and the main therapeutic regimen used was a combination of other antibiotics, anticoagulants, azithromycin, corticosteroids and chloroquine/hydroxychloroquine. Conclusion: the study reveals a population of men, over 60 years of age, with a double burden of chronic non-communicable disease.

SARS-CoV-2 infection in patients with or at risk for venereal infections: Incidence and associated factors in a sexual health clinic. / Infección por SARS-CoV-2 en pacientes con o en riesgo de infecciones venéreas: estudio de su incidencia y factores asociados en un centro monográfico de infecciones de transmisión sexual.

BACKGROUND AND OBJECTIVE: SARS-CoV-2 is more easily spread by close contact, which is inherent to sexual intercourse. People with, or at risk for, sexually transmitted infections (STIs) may therefore have higher rates of COVID-19. The aim of this study was to estimate SARS-CoV-2 antibody seroprevalence in people seen at a dedicated STI clinic, compare our findings to the estimated seroprevalence in the local general population, and study factors associated with SARS-CoV-2 infection in this setting. MATERIAL AND METHODS: Cross-sectional observational study including consecutive patients older than 18 years of age who had not yet been vaccinated against COVID-19 and who underwent examination or screening at a dedicated municipal STI clinic in March and April 2021. We ordered rapid SARS-CoV-2 serology and collected information on demographic, social, and sexual variables, STI diagnoses, and history of symptoms compatible with SARS-CoV-2 infection. RESULTS: We studied 512 patients (37% women). Fourteen (24.2%) had a positive SARS-CoV-2 test. Variables associated with positivity were use of FFP2 masks (odds ratio 0.50) and a higher-than-average number of sexual partners (odds ratio 1.80). Use of FFP2 masks was not randomly distributed in this sample. CONCLUSIONS: Sexually active members of the population in this study had a higher incidence of SARS-CoV-2 infection than the general population. The main route of infection in this group appears to be respiratory, linked to close contact during sexual encounters; sexual transmission of the virus is probably limited.

Prevalência de tuberculose, COVID-19, condições crônicas e vulnerabilidades entre migrantes e refugiados: inquérito eletrônico

Objetivo: analisar a prevalência de tuberculose, coronavírus, condições crônicas e vulnerabilidades entre migrantes e refugiados no Brasil. Método: trata-se de estudo transversal, do tipo inquérito eletrônico, realizado com migrantes internacionais durante a pandemia de COVID-19. Para a análise, aplicou-se estatística descritiva, com cálculo de medidas de posição e de dispersão. Quanto às variáveis categóricas, estimaram-se as frequências relativas e absolutas. Resultados: participaram do estudo 553 migrantes e refugiados, verificando-se prevalência de 3,07% de tuberculose, 7,2% de COVID-19 e 27,3% de condições crônicas. Entre as vulnerabilidades, 32% referiram desemprego, 37,6% mudaram para o Brasil em decorrência da situação social do seu país e 33,6% residiam em asilo e ou abrigo. Conclusão: a tuberculose, as doenças crônicas e a COVID-19 apresentaram maior prevalência em migrantes e refugiados que na população em geral. Por tratar-se de uma população ainda com grande dificuldade de acesso aos serviços de saúde e aos sistemas de proteção social, o estudo subsidiará, com base em evidências, as políticas públicas, o atendimento do enfermeiro e a incorporação de novas rotinas no serviço.Alternate :Goal:to analyze the prevalence of tuberculosis, coronavirus, chronic conditions and vulnerabilities among migrants and refugees in Brazil. Method:this is a cross-sectional study, of the electronic survey type, carried out with international migrants during the COVID-19 pandemic. For the analysis, descriptive statistics were applied, with the calculation of position and dispersion measures. As for categorical variables, relative and absolute frequencies were estimated. Results:553 migrants and refugees participated in the study, verifying a prevalence of 3.07% of tuberculosis, 7.2% of COVID-19 and 27.3% of chronic conditions. Among the vulnerabilities, 32% reported unemployment, 37.6% moved to Brazil due to the social situation in their country and 33.6% resided in asylum and/or shelter. Conclusion:tuberculosis, chronic diseases and COVID-19 were more prevalent in migrants and refugees than in the general population. As this is a population that still has great difficulty in accessing health services and social protection systems, the study will support, based on evidence, public policies, nursing care and the incorporation of new routines in the service.

Healthcare aspects of peritonsillar infection before and during the COVID-19 pandemic.

INTRODUCTION: This study assessed if the healthcare system overload and the organizational changes made in response to COVID-19 may be having an impact on clinical and epidemiological characteristics of the peritonsillar infection (PTI). MATERIALS AND METHODS: In a retrospective longitudinal and descriptive follow-up, we reviewed the circumstances of the patients attended during 5 years, from 2017 to 2021, in two hospitals, one regional and other tertiary. Variables related to underlying pathology, history of tonsillitis, time of evolution, previous visits to Primary Care, diagnostic findings, abscess/phlegmon ratio, and length of hospital stay were recorded. RESULTS: From 2017 to 2019, the incidence of the disease ranged between 14 and 16 cases/100,000 inhabitants-year, and decreased to 9.3 in 2020, a 43% less. Patients with PTI consulting in pandemic time were visited much less often in Primary Care services. They showed a greater severity of symptoms and the period of time between their appearance and diagnosis was longer. Additionally, there were more abscesses and the need for hospital admission greater than 24h was 66%. There was hardly a causal relationship with acute tonsillitis, although 66% of the patients evidenced history of recurrent tonsillitis, and 71% concomitant pathology. All these findings showed statistically significant differences with the pre-pandemic cases. CONCLUSIONS: The protection of airborne transmission, the social distancing and the lockdown adopted in our country are measures that seem having been able to modify the evolution of PTI, with a much lower incidence, a longer recovery period and a minimal relationship with acute tonsillitis.

[COVID-19 epidemiology in health and social health workers in the health area of A Coruña and Cee]. / Epidemiología de la COVID-19 entre el personal de centros sanitarios y sociosanitarios del área sanitaria de A Coruña y Cee.

OBJECTIVE: Since the beginning of the pandemic, it has become necessary to know the epidemiological evolution of SARS-CoV-2. Therefore, this study aims to describe the characteristics of the casuistry of COVID-19 in health and social-health workers in the health area of A Coruña and Cee during the first epidemic wave, as well as to determine the association between the clinical profile and/or its duration and the condition of RT-PCR repositivization. MATERIALS AND METHODS: During the study period, 210 cases belonging to healthcare and social-healthcare workers from the healthcare area of A Coruña and Cee were diagnosed. A descriptive analysis of sociodemographic factors was carried out, as well as the search for association between the clinical picture and the duration of detection of a positive RT-PCR. RESULTS: The most affected categories were nursing (33.3%) and nursing assistants (16.2%). The mean time taken for cases to become RT-PCR negative was 18.3±9.1 days, with a median of 17. It was observed that 26 cases (13.8%) had a positive result in a subsequent RT-PCR, without meeting criteria for reinfection. The existence of skin manifestations and arthralgias was associated with repositivization after adjusting for age and sex (OR=4.6 and OR=6.5, respectively). CONCLUSIONS: In healthcare professionals diagnosed with COVID-19 during the first wave, symptoms such as dyspnea, skin manifestations and arthralgias led to RT-PCR repositivization after a previous negative result and without meeting criteria for reinfection.

[Study of incidence of COVID-19 in Spain and its relationship to geographical province distribution]. / Estudio de la incidencia de COVID-19 en España y su relación geográfica provincial.

BACKGROUND: The aim of this study was to determine incidence of COVID-19 in relationship to geographical distribution among Spain. METHOD: Cluster analysis taking into consideration the incidence of COVID-19 in the provinces and autonomous cities of Spain in each of the first six waves of the pandemic. RESULTS: All the provinces of the Canary Islands, Catalonia and Andalusia form independent clusters. In Comunidad Valenciana, Galicia, País Vasco and Aragón two out of three provinces (three out of four in Galicia) were in the same cluster, with no other provinces. DISCUSSION: The incidence of COVID-19 in Spain in the first six waves forms clusters that reproduce the territorial division of Spain into autonomous communities. Although this could be explained by greater mobility within a community, it cannot be ruled out that this distribution is due to differences in screening, diagnosis, registration or reporting of COVID-19 cases.

Appropriateness of routine pre-endoscopic SARS-CoV-2 screening with RT-PCR in asymptomatic individuals and its impact on delayed diagnosis.

AIMS: Endoscopy units are considered to be at an increased risk of infection by SARS-CoV-2. Our aim is to assess the correlation between pre-endoscopic screening with reverse-transcription-polymerase-chain-reaction (RT-PCR) in asymptomatic individuals scheduled for elective endoscopy and the epidemiological data published by the local Health Administration. PATIENTS AND METHODS: Observational retrospective study collecting the results of our screening strategy spanning June/2020-June/2021, the effective potential growth (EPG), an index measuring the outbreak risk, and the 7 and 14-day cumulative incidence (CI). Indication, delay and the findings of the endoscopic examinations were registered for RT-PCR positive patients. RESULTS: A total of 5808 tests were performed, yielding 125 positive results (2.15%). All positive tests occurred in weeks of high/very high risk (EPG>100) with the highest monthly rate being 9.36%, recorded in January/2021. A significant correlation (rho=0.796; p<0.001) between weekly positive rates and EPG was observed, and a significantly lower weekly number of positive tests was recorded when EPG<100. Planning the screening strategy one week ahead according to EPG>100 would have avoided up to 826 tests with only one positive result to account for. One hundred and thirteen individuals tested positive and 89 endoscopies were delayed. The most common findings were colon polyps, colorectal cancer and gastric metaplasia. Oncological diagnosis was delayed 50±3 days. CONCLUSIONS: No positive RT-PCR test were registered out of high-risk periods. Epidemiological administrative data in the preceding two weeks showed a significant correlation with screening results and could be useful to plan pre-endoscopic screening and avoid unnecessary tests.

Koronavírus-világjárvány - a COVID-19-kaleidoszkóp ma (2022. május).

The article attempts to review the principal epidemiological data of the coronavirus pandemic (COVID-19) based on the rapidly changing and expanding international and domestic literature. The review covers the so-called "long COVID-19" as well as the latest pharmacological and immunotherapeutic developments. The manuscript deals with the future of innovative vaccinology, the so-called 'pan-vaccines' developed through artificial intelligences and nanotechnology. Orv Hetil. 2022; 163(24): 935-942.

Geotechnologies applied in epidemiological studies on cases of covid-19: a narrative review / Geotecnologias aplicadas em estudos epidemiológicos sobre os casos de covid-19: revisão narrativa / Geotecnologías aplicadas en estudios epidemiológicos sobre casos de covid-19: revisión narrativa

Background and objectives: the applied geotechnologies are essential in helping the development of epidemiological studies that aim to identify and distribute health events in specific populations and territories, in addition to verifying the factors that influence the occurrence of these events, intending to apply the evidence in strategies of disease planning and control as in the covid-19 pandemic. This study aimed to present the scientific evidence that has been produced on geotechnologies applied in epidemiological studies on cases of covid-19. Methods: this is a descriptive narrative literature review (NLR). To guide the study, the following research question was elaborated: what has been studied about applied geotechnologies in epidemiological research on covid-19 cases? The search was carried out in October 2021, using the descriptors Geographic Information Systems AND Covid-19 OR SARS-CoV-2 AND Epidemiology AND Spatial Analysis, in Virtual Health Library, Scopus, Web of Science, Portal CAPES. Complementarily, a search was carried out for epidemiological bulletins and booklets on the Brazilian Ministry of Health website. Results: nineteen sources of information were selected that fit the objectives for the discussion construction, with three categories of analysis being listed: Geotechnology application; Information management; Challenges of epidemiological studies that use secondary data. Conclusion: geotechnology use in epidemiological studies on covid-19 in identifying areas at risk for the infection spread was such remarkable.(AU)

Justificativa e objetivos: as geotecnologias aplicadas são essenciais para auxiliar o desenvolvimento de estudos epidemiológicos que visam identificar e distribuir eventos de saúde em populações e territórios específicos, além de verificar os fatores que influenciam a ocorrência desses eventos, pretendendo aplicar as evidências em estratégias de planejamento e controle de doenças como na pandemia de covid-19. Este estudo teve como objetivo apresentar as evidências científicas que vêm sendo produzidas sobre geotecnologias aplicadas em estudos epidemiológicos de casos de covid-19. Métodos: trata-se de uma revisão de literatura narrativa descritiva (NLR). Para nortear o estudo, elaborou-se a seguinte questão de pesquisa: o que tem sido estudado sobre as geotecnologias aplicadas na pesquisa epidemiológica dos casos de covid-19? A busca foi realizada no mês de outubro de 2021, utilizando os descritores Geographic Information Systems AND Covid-19 OR SARS-CoV-2 AND Epidemiology AND Spatial Analysis, na Biblioteca Virtual em Saúde, Scopus, Web of Science, Portal CAPES. Complementarmente, foi realizada busca de boletins e cartilhas epidemiológicas no site do Ministério da Saúde do Brasil. Resultados: foram selecionadas dezenove fontes de informação que se enquadram nos objetivos para a construção da discussão, sendo elencadas três categorias de análise: Aplicação da geotecnologia; Gestão da informação; Desafios dos estudos epidemiológicos que utilizam dados secundários. Conclusão: o uso da geotecnologia em estudos epidemiológicos da covid-19 na identificação de áreas de risco para a propagação da infecção foi notável.(AU)

Justificación y objetivos: las geotecnologías aplicadas son esenciales para ayudar al desarrollo de estudios epidemiológicos que tengan como objetivo identificar y distribuir eventos de salud en poblaciones y territorios específicos, además de verificar los factores que influyen en la ocurrencia de estos eventos, con la intención de aplicar la evidencia en estrategias de planificación y control de enfermedades como en la pandemia de covid-19. Este estudio tuvo como objetivo presentar la evidencia científica que se ha producido sobre geotecnologías aplicadas en estudios epidemiológicos sobre casos de covid-19. Métodos: se trata de una revisión descriptiva narrativa de la literatura (NLR). Para orientar el estudio se elaboró la siguiente pregunta de investigación: ¿Qué se ha estudiado sobre geotecnologías aplicadas en la investigación epidemiológica de casos de covid-19? La búsqueda se realizó en octubre de 2021, utilizando los descriptores Sistemas de Información Geográfica Y Covid-19 O SARS-CoV-2 Y Epidemiología Y Análisis Espacial, en Biblioteca Virtual en Salud, Scopus, Web of Science, Portal CAPES. Complementariamente, se realizó una búsqueda de boletines y folletos epidemiológicos en el sitio web del Ministerio de Salud de Brasil. Resultados: fueron seleccionadas diecinueve fuentes de información que se ajustan a los objetivos para la construcción de la discusión, siendo enumeradas tres categorías de análisis: aplicación de la geotecnología; Gestión de la información; Retos de los estudios epidemiológicos que utilizan datos secundarios. Conclusión: el uso de geotecnología en estudios epidemiológicos sobre covid-19 para identificar áreas en riesgo de propagación de la infección fue tan notable.(AU)

What is post-COVID-19 syndrome? Definition and update.

This work addresses the origin and development of post-COVID-19 syndrome, which consists of the persistence of different symptoms over time as a consequence of SARS-CoV-2 infection. Based on a narrative review of the scientific literature, a brief analysis of the new term is made, specifying the conceptual definition, characteristic symptoms, the various implications for people's health, and the responses to specific care measures that have been implemented. It concludes with a wake-up call to the governments of Latin America and the Caribbean in order for care and surveillance to be provided to this public health problem.

Este trabajo aborda el origen y el desarrollo del síndrome pos-COVID-19, el cual consiste en la persistencia a través del tiempo de diferentes síntomas como consecuencia de la infección por SARS-CoV-2. A partir de una revisión narrativa de la literatura científica, se realiza un breve recorrido sobre el nuevo término y se precisa la definición conceptual, los síntomas característicos, las diversas implicaciones en la salud de las personas y las respuestas de atención específica que se han implementado. Se concluye con una llamada de atención a los gobiernos de América Latina y el Caribe para dar tratamiento y seguimiento a este problema de salud pública.

Epidemiological profile of death resulting from Covid-19 in a municipality in southwest of Paraná / Perfil epidemiológico de óbitos decorrentes da Covid-19 em um município do sudoeste do Paraná / Perfil epidemiológico de las muertes por Covid-19 en un municipio del suroeste de Paraná

Introdução: No final do ano de 2019 surgiu na China uma doença infectocontagiosa de característica respiratória e alto grau de disseminação até então desconhecida. No Brasil o primeiro caso de Covid-19 foi confirmado no final de fevereiro de 2020 e a primeira morte em meados de março. Segundo dados da plataforma Coronavírus Brasil, em 17 de março de 2021, houve registro de 11.603.535 casos confirmados e 282.127 óbitos. Objetivo: Descrever o perfil de pessoas que morreram tendo como causa básica do óbito a Covid-19, em um município do Sudoeste do Paraná, entre os anos de 2020 e 2021. Metodologia: Trata-se de um estudo transversal, descritivo, documental de caráter quantitativo que foi realizado na prefeitura municipal de Francisco Beltrão. Resultados: Houve prevalência de óbitos em pacientes do sexo masculino, idosos, com presença de alguma comorbidade associada, sendo hipertensão a mais citada (50,8%). Os sintomas mais prevalentes foram tosse (74,4%), dispneia (56,3%) e saturação < 95% (48,3%), necessitando ainda de hospitalização em algum período da doença (94,1%), sendo os leitos de Sistema Único de Saúde os mais procurados (74,4%). Quanto à taxa de ocupação 49,6% dos casos necessitou apenas de leitos de enfermaria e 42% unidades de terapia intensiva. Discussão: Diversas pesquisas apontam que o sexo masculino é o mais acometido por condições graves de saúde, devido à demora na busca de assistência médica. No que se refere à idade, neste estudo, a prevalência de óbitos se deu entre 71 e 75 anos (15,1%) o que justifica que o envelhecimento é um fator de risco elevado para complicações da doença. Durante a análise dos dados, notou- se que grande parte dos pacientes que tiveram como desfecho o óbito, possuíam algum fator associado, dentre os mais citados, verificou-se a Hipertensão Arterial Sistêmica (50,8%) Diabetes Mellitus (24,8%), doenças cardiovasculares (23,9%) e obesidade (14,7%). No que diz respeito à hospitalização, nesse estudo notou-se que 74,4% da amostra foram hospitalizadas em leitos de SUS, 18,5% em hospitais particulares e 7,1% não possuíam essa informação. Conclusão: É possível observar a importância do estudo epidemiológico para identificar o perfil da população em risco, podendo auxiliar no planejamento do atendimento, rastreamento e controle da doença, além de conhecer a evolução da patologia, a fim de buscar ações adequadas para seu enfrentamento.

Introduction: At the end of 2019, a previously unknown infectious disease with respiratory characteristics and a high degree of dissemination emerged in China. In Brazil the first case of Covid-19 was confirmed in late February 2020 and the first death in mid-March. According to data from the Coronavirus Brazil platform, as of March 17, 2021, 11,603,535 confirmed cases and 282,127 deaths were recorded. Objective: To describe the profile of people who died with Covid-19 as the underlying cause of death in a city in southwestern Paraná between the years 2020 and 2021. Methodology: This is a cross-sectional, descriptive, documental, quantitative study carried out at the Francisco Beltrão City Hall. Results: There was a prevalence of deaths in male patients, elderly, with the presence of some associated comorbidity, hypertension being the most cited (50.8%). The most prevalent symptoms were cough (74.4%), dyspnea (56.3%) and saturation < 95% (48.3%), requiring hospitalization in some period of the disease (94.1%), and the Unified Health System beds were the most sought (74.4%). As for the occupancy rate, 49.6% of the cases required only ward beds and 42% intensive care units. Discussion: Several studies show that men are the most affected by serious health conditions, due to the delay in seeking medical assistance. Regarding age, in this study, the prevalence of deaths was between 71 and 75 years (15.1%), which justifies that aging is a high risk factor for disease complications. During data analysis, it was noted that most patients who died had some associated factor, among the most cited were systemic arterial hypertension (50.8%), diabetes mellitus (24.8%), cardiovascular diseases (23.9%) and obesity (14.7%). Regarding hospitalization, in this study it was noted that 74.4% of the sample were hospitalized in SUS beds, 18.5% in private hospitals, and 7.1% did not have this information. Conclusion: It is possible to observe the importance of the epidemiological study to identify the profile of the population at risk, which can help in planning care, tracking and control of the disease, besides knowing the evolution of the pathology in order to seek appropriate actions for its confrontation

Introducción: A finales del año 2019 apareció en China una enfermedad infecto- contagiosa de característica respiratoria y alto grado de diseminación desconocida hasta entonces. En Brasil se confirmó el primer caso de Covid-19 a finales de febrero de 2020 y la primera muerte a mediados de marzo. Según los datos de la plataforma Coronavirus Brasil, hasta el 17 de marzo de 2021, había 11.603.535 casos confirmados y 282.127 muertes. Objetivo: Describir el perfil de las personas fallecidas con Covid-19 como causa subyacente de muerte en una ciudad del sudoeste de Paraná entre los años 2020 y 2021. Metodología: Se trata de un estudio transversal, descriptivo, documental de carácter cuantitativo que se realizó en la prefectura municipal de Francisco Beltrão. Resultados: Hubo una prevalencia de muertes en pacientes masculinos, de edad avanzada, con presencia de alguna comorbilidad asociada, siendo la hipertensión la más citada (50,8%). Los síntomas más prevalentes fueron la tos (74,4%), la disnea (56,3%) y la saturación < 95% (48,3%), requiriendo hospitalización en algún periodo de la enfermedad (94,1%), siendo las camas del Sistema Único de Salud las más solicitadas (74,4%). En cuanto a la tasa de ocupación, el 49,6% de los casos sólo necesitaban camas de sala y el 42% unidades de cuidados intensivos. Discusión: Varias investigaciones señalan que el género masculino es el más afectado por las condiciones de salud graves, debido al retraso en la búsqueda de asistencia médica. En cuanto a la edad, en este estudio, la prevalencia de muertes se produjo entre los 71 y los 75 años (15,1%), lo que justifica que el envejecimiento sea un factor de riesgo elevado para las complicaciones de la enfermedad. Durante el análisis de los datos, se observó que la mayoría de los pacientes que fallecieron tenían algún factor asociado, entre los más citados estaban la Hipertensión Arterial Sistémica (50,8%), la Diabetes Mellitus (24,8%), las enfermedades cardiovasculares (23,9%) y la obesidad (14,7%). En lo que respecta a la hospitalización, en este estudio se observó que el 74,4% de la muestra estaba hospitalizada en camas del SUS, el 18,5% en hospitales privados y el 7,1% no tenía esta información. Conclusión: Es posible observar la importancia del estudio epidemiológico para identificar el perfil de la población en riesgo, pudiendo ayudar en la planificación de la atención, el rastreo y el control de la enfermedad, además de conocer la evolución de la patología, con el fin de buscar las acciones adecuadas para su enfrentamiento.

What is post-COVID-19 syndrome? Definition and update / ¿Qué es el síndrome pos-COVID-19? Definición y actualización

Resumen Este trabajo aborda el origen y el desarrollo del síndrome pos-COVID-19, el cual consiste en la persistencia a través del tiempo de diferentes síntomas como consecuencia de la infección por SARS-CoV-2. A partir de una revisión narrativa de la literatura científica, se realiza un breve recorrido sobre el nuevo término y se precisa la definición conceptual, los síntomas característicos, las diversas implicaciones en la salud de las personas y las respuestas de atención específica que se han implementado. Se concluye con una llamada de atención a los gobiernos de América Latina y el Caribe para dar tratamiento y seguimiento a este problema de salud pública.

Abstract This work addresses the origin and development of post-COVID-19 syndrome, which consists of the persistence of different symptoms over time as a consequence of SARS-CoV-2 infection. Based on a narrative review of the scientific literature, a brief analysis of the new term is made, specifying the conceptual definition, characteristic symptoms, the various implications for people's health, and the responses to specific care measures that have been implemented. It concludes with a wake-up call to the governments of Latin America and the Caribbean in order for care and surveillance to be provided to this public health problem.

Impact of COVID-19 pandemic on notifiable diseases in Northern Brazil / Impacto da COVID-19 em doenças de notificação compulsória no Norte do Brasil / Impacto de la COVID-19 en las enfermedades de notificación compulsoria del Norte de Brasil

Objetivo: Avaliar o impacto da pandemia COVID-19 em doenças de notificação compulsória no Norte do Brasil. Métodos: Estudo descritivo e retrospectivo realizado com dados das bases Sinan (Sistema de Informação de Agravos de Notificação) e SIH/SUS (Sistema de Informações Hospitalares do SUS) sobre meningite bacteriana e viral, dengue, febre hemorrágica da dengue, arboviroses, sífilis, tuberculose, hanseníase e hepatites virais. Utilizou-se estatística descritiva para avaliação da variação nos números absolutos das notificações e internações do período de 2015 a 2020 e suas variações médias. Resultados: As notificações e internações de meningite, arboviroses não-dengue, hanseníase, leptospirose e hepatites virais, em geral, demonstraram redução de 50 até 80% em relação a períodos anteriores. Houve variabilidade regional com dengue e febre hemorrágica da dengue, com aumentos e reduções independentes. As sífilis adquirida, gestacional e congênita demonstraram queda de até 60% nas notificações e nas internações, exceto sífilis congênita, que se manteve em estabilidade. As notificações e as internações de tuberculose se mantiveram estáveis em toda a região. Conclusão: Houve redução geral de mais da metade das notificações e das internações hospitalares, apresentando um impacto variável, dependendo do Estado e do processo de endemia de cada sub-região.

Objective: To assess the impact of the COVID-19 pandemic on notifiable diseases in Northern Brazil. Methods: A descriptive retrospective study was conducted using data from the Notifiable Disease Information System (Sistema de Informação de Agravos de Notificação ­ Sinan) and SUS Hospital Information System (Sistema de Informações Hospitalares do SUS ­ SIH/SUS) on bacterial and viral meningitis, dengue, dengue hemorrhagic fever, arboviruses, syphilis, tuberculosis, leprosy, and viral hepatitis. Descriptive statistics was used to assess the variation in absolute numbers of notifications and hospitalizations from 2015 to 2020 and their average variations. Results: Notifications and hospitalizations for meningitis, non-dengue arboviruses, leprosy, leptospirosis, and viral hepatitis exhibited a general decrease of 50 to 80% compared to previous years. There was regional variation in dengue and dengue hemorrhagic fever, with independent increases and decreases. Acquired, gestational and congenital syphilis presented a 60% decrease in notifications and hospitalizations, except for congenital syphilis, which remained stable. Tuberculosis notifications and hospitalizations remained stable in the entire region. Conclusion: There was an overall decrease of more than a half of notifications and hospitalizations, representing a variable impact depending on the state and the endemic process of each subregion.

Objetivo: Evaluar el impacto de la pandemia de la COVID-19 en las enfermedades de notificación compulsoria del Norte de Brasil. Métodos: Estudio descriptivo y retrospectivo realizado con datos de las bases SINAN (Sistema de Información de Agravios de Notificación) y SIH/SUS (Sistema de Informaciones Hospitalarias del SUS) sobre la meningitis bacteriana y viral, el dengue, la fiebre hemorrágica del dengue, las arbovirosis, la sífilis, la tuberculosis, la lepra y las hepatitis virales. Se utilizó de la estadística descriptiva para la evaluación de la variación de los números absolutos de las notificaciones y los ingresos del periodo entre 2015 y 2020 y sus variaciones medias. Resultados: Las notificaciones y los ingresos de meningitis, arbovirosis no-dengue,la lepra, la leptospirosis y las hepatitis virales, en general, han demostrado una disminución del 50 hasta el 80% respecto los periodos anteriores. Hubo variabilidad por región respecto el dengue y fiebre hemorrágica del dengue con subidas y bajadas independientes. Las sífilis adquirida, gestacional y congénita han demostrado caída hasta el 60% de las notificaciones e ingresos excepto la sífilis congénita que se mantuvo estable. Las notificaciones y los ingresos por tuberculosis se mantuvieron estables em toda la región. Conclusión: Hubo una disminución general de más de la mitad de las notificaciones y los ingresos hospitalarios, presentando un impacto variable, a depender del Estado y del proceso de endemia de cada sub-región.

Efetividade da auriculoterapia na redução de estresse em trabalhadores de saúde: ensaio clínico controlado randomizado

Objetivo: avaliar a efetividade da auriculoterapia na redução do estresse ocupacional em trabalhadores de saúde da Estratégia de Saúde da Família durante a pandemia da COVID-19. Método: ensaio clínico controlado randomizado em dois grupos: grupo auriculoterapia para o estresse e grupo placebo. Foi utilizado o teste de Shapiro-Wilk para avaliar a normalidade dos dados. O teste ANOVA de medidas repetidas e o teste post-hoc Tukey foram aplicados para o grupo com amostras normais. Já o teste de Friedman e de Durbin-Conover foram utilizados no grupo com distribuição não normal. Para o tamanho do efeito da terapia, foi calculado o índice d de Cohen. Considerou-se o nível de significância de 95% e valor p<0,05. Resultados: o grupo auriculoterapia apresentou redução do estresse ocupacional de 16,3 e 23,7% após a terceira e sexta sessões de auriculoterapia, com índices d de Cohen de 1,12 (grande efeito) e 1,82 (efeito muito grande), respectivamente. Conclusão: a auriculoterapia mostrou-se efetiva na redução do estresse ocupacional em trabalhadores de saúde da Estratégia Saúde da Família durante a pandemia da COVID-19. Sugere-se que novos estudos sejam desenvolvidos durante e após a pandemia de maneira a melhorar a qualidade de vida dos trabalhadores de saúde. Registro ReBEC: RBR - 38hjyt3.

Efectividad de la auriculoterapia para la reducción del estrés de trabajadores de la salud: ensayo clínico controlado aleatorizado

Objetivo: evaluar la efectividad de la auriculoterapia para la reducción del estrés laboral en trabajadores de salud de la Estrategia Salud de la Familia durante la pandemia de COVID-19. Método: ensayo clínico controlado aleatorizado en dos grupos: grupo auriculoterapia para el estrés y grupo placebo. Se utilizó la prueba de Shapiro-Wilk para evaluar la normalidad de los datos. Al grupo con muestras normales se les aplicó la prueba ANOVA de medidas repetidas y la prueba post-hoc de Tukey. Se utilizaron las pruebas de Friedman y Durbin-Conover en el grupo con distribución no normal. Para el tamaño del efecto de la terapia se calculó el índice d de Cohen. Se consideró un nivel de significación del 95% y un valor de p <0,05. Resultados: el grupo auriculoterapia mostró una reducción del estrés laboral de 16,3 y 23,7% después de la tercera y sexta sesión de auriculoterapia, con índices d de Cohen de 1,12 (efecto grande) y 1,82 (efecto muy grande), respectivamente. Conclusión: la auriculoterapia demostró ser eficaz para la reducción del estrés laboral en trabajadores de la salud de la Estrategia Salud de la Familia durante la pandemia de COVID-19. Se sugiere desarrollar nuevos estudios durante y después de la pandemia con el fin de mejorar la calidad de vida de los trabajadores de la salud. Registro ReBEC: RBR - 38hjyt3.

Epidemiological Characterization: Peritonitis Mortality Rate and Swaroop Index in the period 2017 - 2021, in Chile

Introduction: Peritonitis reaches an overall mortality up to 60%. Given the lack of national epidemiological studies, it is proposed the calculation of the mortality rate (MR) due to peritonitis between the years 2017-2021 in Chile. Methodology: Descriptive, ecological study about deaths by peritonitis between 2017 and 2021 in Chile (N=1,741), in a population older than 15 years old according to age group, sex and region with data obtained from Departamento de Estadística e Información en Salud. Descriptive statistics were used, MR calculation and Swaroop Index (SI). It did not require approval by an ethics committee. Results: A MR of 2.47/100.000 was calculated between the years 2017 and 2021, with 2020 being the highest with 3.07. The female sex presented a rate of 2.65. The age group with the highest MR is 80 and over with 141.7/100.000. For the SI by region, the XV and XII regions lead with 100%, the lowest being XI region with 83.3%. Discussion:: The peak of MR for the year 2020 coincides with the Covid-19 pandemic and the highest postoperative mortality on infected patients. The SI remains above 90% in the country, except in X and XI regions, probably due to the lower availability of high complexity centers. Conclusion: Given the lack of recent mortality data for peritonitis, a local epidemiological update was carried out, with a regional comparative perspective regarding MR in the general population and in those over 50 years old. (English) [ FROM AUTHOR]

COVID-19 en receptores de trasplante renal: ¿qué hemos aprendido tras 18 meses de pandemia?

La infección por el SARS-CoV-2 (COVID-19) ha supuesto un importante impacto en la actividad trasplantadora en nuestro país. En su condición de paciente inmunodeprimido y con frecuentes comorbilidades, era esperable que la mortalidad y el riesgo de complicaciones asociadas a la COVID-19 en el receptor de trasplante renal (TR) fueran mayores en comparación con la población general, si bien la información al respecto en los primeros meses de la pandemia era muy limitada. Desde marzo de 2020 hemos mejorado rápidamente nuestro conocimiento acerca de la epidemiología, características clínicas y manejo de la COVID-19 post-trasplante. La presente revisión pretende recopilar la información disponible a julio de 2021 en respuesta a una serie de cuestiones relevantes: ¿cómo se manifiesta clínicamente la infección por SARS-CoV-2 en receptores de TR?, ¿cuáles son sus factores pronósticos?, ¿es más grave la COVID-19 en el contexto del TR respecto a los pacientes inmunocompetentes?, ¿de qué opciones de tratamiento antiviral disponemos actualmente para el receptor de TR?, ¿cuál es la experiencia disponible con los tratamientos inmunomoduladores? y, por último, ¿son eficaces las vacunas frente a la COVID-19 basadas en ARN mensajero en esta población?. A pesar de los avances realizados, aún son varios los aspectos que debemos mejorar en nuestro abordaje de la infección por SARS-CoV-2 en el ámbito específico del TR.Alternate : SARS-CoV-2 infection (COVID-19) has profoundly impacted transplant activity in our country. As immunocompromised hosts with common comorbidities, kidney transplant (KT) recipients were expected to have higher mortality and risk of complications associated to COVID-19 compared to the overall population. The available experience at the beginning of the pandemic, however, was very limited. Since March 2020 our knowledge on the epidemiology, clinical features and management of post-transplant COVID-19 has rapidly evolved. The present review is aimed at summarizing the information generated by July 2021 to answer a number of relevant questions: How does SARS-CoV-2 infection present in KT recipients? What are the prognostic factors? Does COVID-19 entail a worse prognosis in the setting of KT as compared to non-immunocompromised individuals? What are the antiviral agents currently available for KT recipients? What is the experience with the use of immunomodulatory therapies? And lastly, are mRNA-based COVID-19 vaccines effective in this patient population? Despite notable advances achieved, we should still improve various aspects of our approach to SARS-CoV-2 infection in the specific setting of KT.